Effect of single-dose intravenous ibuprofen before surgery on post-anesthesia pain: a systematic review and meta-analysis

Introduction: During the last few years, the trend of using non-opioid drugs for the management of pain after surgery has been highly welcomed, and on the other hand, considering the contradictory results of the preventive use of intravenous ibuprofen before surgery, the present study aimed at the effect of a single dose of intravenous ibuprofen before surgery. A systematic review and meta-analysis was conducted on post-anesthesia pain surgery. Methods: This study was conducted as a systematic review and meta-analysis in the first six months of 1401 based on the PRISMA statement. For this purpose, the keywords of ibuprofen, intravenous, post-surgical pain, analgesia, opioid and analgesia under patient control in the databases PubMed, Scopus, MEDLINE, Embase, Cochrane Center for Controlled Trials and Web of Science, Mag Iran and SID databases. Results: Examining pain intensity at 12 hours (MD=-1.64 (-2.56, -0.72), 95%CI P=0.001 and I=95%) and 24 hours (-0.58) MD = (-0.18, -0.99) 95% CI- P = 0.001 and I = 90%) after surgery indicated that prophylactic administration of ibuprofen significantly reduced pain intensity. Conclusion: The administration of a single prophylactic dose of intravenous ibuprofen leads to a decrease in pain intensity during the first 24 hours after surgery, however, its effects decrease over time.